PSL Spheres Technical Resource is published by Applied Physics Corporation — precision technologies since 1992.719-428-4042 · [email protected]
Particle format

Choose the particle format around the delivery method.

Wet, dry and deposited forms may share a material name while presenting fundamentally different preparation, safety and metrology requirements.

Format distinction

Aqueous suspension and dry microspheres solve different delivery problems

FormatAdvantagesRisks / controls
Aqueous PSL suspensionControlled wet handling, dilution, liquid-counter use, aerosol feedBackground contamination, adsorption, dilution error, surfactant, storage
Dry microspheresDirect dry blending or dry-delivery possibilitiesStatic, dust, agglomeration, mass-based preparation, inhalation and handling controls
Deposited wafer artifactReady-to-scan surface referenceSurface contamination, handling damage, tool compatibility and recertification
Do not create a dry standard by accident

Evaporating an aqueous bottle is not a validated conversion

Drying can leave surfactant or nonvolatile residue, create agglomerates and alter the delivered size distribution. A dry-particle need should be specified as such and matched to a product or validated preparation method.

Hard stop: do not evaporate an aqueous calibration standard and assume the remaining particles retain the certified delivered population.
Selection questions

Define the downstream process

  • Will the material be diluted, aerosolized, blended, deposited or sampled directly?
  • Is water acceptable in the process?
  • What contamination and residue limits apply?
  • How will concentration be assigned in the chosen format?
  • What safety controls apply to dry powders or aerosols?
  • What certificate data must remain valid after preparation?
Applied Physics review

Specify the format in the requirement brief

Use the technical recommendation form to identify wet, dry, aerosol or wafer-delivered requirements. Applied Physics can then route the inquiry to the correct product family or identify a custom-method need.

Applied Physics technical pathway

Match the standard to the measurement—not the other way around.

Send the instrument, medium, target size, concentration, certificate and packaging requirements to Applied Physics for a technical recommendation.